Circadian Rhythms Research

If you are an Amherst College undergraduate interested in getting involved in research involving mathematics and biology, then please contact me! Several students have worked with me on projects analyzing experimental data on jet lag in mice and on modeling the circadian clock in the brain, including two projects that resulted in published articles. No biology background is necessary, just a willingness to learn!

Wavelet transform

Current topics of interest

Matlab scripts and datasets from the wavelet articles


Ware, K. Rode, C. Robbins, T. Leise, R. Weil, and H. Jansen (2020). The clock keeps ticking: Circadian rhythms of free-ranging polar bears, Journal of Biological Rhythms 35:180-194.

Cenek*, L. Klindziuk*, C. Lopez*, E. McCartney, B. Martin Burgos, S. Tir, M. Harrington, and T. Leise (2020). CIRCADA: Shiny apps for exploration of experimental and synthetic circadian time series with an educational emphasis, Journal of Biological Rhythms 35:214-222.

Leise, A. Goldberg*, J. Michael*, G. Montoya*, S. Solow*, P. Molyneux, R. Vetrivelan, M. Harrington (epub 2018). Recurring circadian disruption alters circadian clock sensitivity to resetting, European Journal of Neuroscience.

D. Liu, A. Stowie, N. de Zavalia, T. Leise, S. Pathak, L. Drewes, A. Davidson, S. Amir, N. Sonenberg, and R. Cao (2018). mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction, PNAS 115(14): E3296-E3304.

E. Winnebeck, D. Fischer, T. Leise, and T. Roenneberg (2018). Dynamics and ultradian structure of human sleep in real life, Current Biology 28:49-59.

T. Noguchi, T. Leise, N. Kingsbury, T. Diemer, L. Wang, M. Henson, and D. Welsh (2017). Calcium Circadian Rhythmicity in the Suprachiasmatic Nucleus: Cell Autonomy and Network Modulation, eNeuro 7 August 2017, ENEURO.0160-17.2017.

T. Leise (2017). Analysis of nonstationary time series for biological rhythms research, Journal of Biological Rhythms 32:187-194.

A. Azzi, J. Evans, T. Leise, J. Myung, T. Takumi, A. Davidson, and S.A. Brown (2017). Network Dynamics Mediate Circadian Clock Plasticity, Neuron 93:441-450.

H. Jansen, T. Leise, G. Stenhouse, K. Pigeon, W. Kasworm, J. Teisberg, T. Radandt, R. Dallmann, S. Brown, and C.T. Robbins (2016). The bear circadian clock doesn’t ‘sleep’ during winter dormancy, Frontiers in Zoology 13:42.

L. Roberts, T. Leise, and T. Holmes (2016). Functional contributions of strong and weak oscillators to synchrony and light-shifted phase dynamics, Journal of Biological Rhythms 31:337-51.

J. Evans, T. Leise, O. Castanon-Cervantes, A. Davidson (2015). Neural correlates of individual differences in circadian behaviour, Proc. R. Soc. B 282:20150769.

J. Evans, T-C. Suen, B. Callif, A. Mitchell, O. Castanon-Cervantes, K. Baker, I. Kloehn, K. Baba, B. Teubner, J.Ehlen, K. Paul, T. Bartness, G. Tosini, T. Leise, and A. Davidson (2015). Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body, BMC Biology 13:43.

L. Roberts, T. Leise, T. Noguchi, A. Galschiodt, J. Houl, D. Welsh, and T. Holmes (2015). Light evokes rapid circadian network oscillator desynchrony followed by gradual phase retuning of synchrony, Current Biology 25:858-67.

E. Manoogian, T. Leise, and E. Bittman (2015). Phase resetting in duper hamsters: Specificity to photic zeitgebers and circadian phase, Journal of Biological Rhythms 30:129-143.

T. Leise (2015). Wavelet-based analysis of circadian behavioral rhythms. In: Seghal, Amita (editor), Circadian Rhythms and Biological Clocks: Methods in Enzymology Volume 551, Academic Press.

C.J. Guenthner, M.E. Luitje, L.A. Pyle, P.C. Molyneux, J.K. Yu, A.S. Li, T.L. Leise, and M. Harrington (2014). Circadian rhythms of PER2::LUC in individual primary mouse hepatocytes and cultures, PLoS ONE 9:e87573.

J. Evans, T. Leise, O. Castanon-Cervantes, A. Davidson (2013). Dynamic interactions mediated by non-redundant signaling mechanisms couple circadian clock neurons, Neuron 80:973-83

T. Leise (2013). Wavelet analysis of circadian and ultradian behavioral rhythms, Journal of Circadian Rhythms 11:5.

T. Leise, M. Harrington, P. Molyneux, I. Song, H. Queenan, E. Zimmerman, G. Lall, and S. Biello (2013). Voluntary exercise can strengthen the circadian system in aged mice, AGE 35:2137-2152.

T. Leise, P. Indic, M.J. Paul, and W.J. Schwartz (2013). Wavelet meets actogram, J. Biol. Rhythms 28:62-68.

A. Cohen, T. Leise, and D. K. Welsh (2012).  Bayesian statistical analysis of circadian time series, Journal of Theoretical Biology 314:182-191.

M. Sellix, J. Evans, T. Leise, O. Castanon-Cervantes, D. Hill, P. DeLisser, G. Block, M. Menaker, and A. Davidson (2012). Aging differentially affects the re-entrainment response of central and peripheral circadian oscillators, Journal of Neuroscience 32:16193-16202.

T. Leise, C. Wang, P. Gitis, and D. K. Welsh (2012).  Persistent Cell-Autonomous Circadian Oscillations in Fibroblasts Revealed by Six-Week Single-Cell Imaging of PER2::LUC Bioluminescence, PLoS ONE 7(3): e33334, doi:10.1371/journal.pone.0033334.

M.E. Harrington and T. Leise (2011). Wavelet-based time series analysis of circadian rhythms, J. Biol. Rhythms 26:454-463.

J. A. Evans, T. Leise, O. Castanon-Cervantes, A. Davidson (2011.)  Intrinsic regulation of spatiotemporal organization within the suprachiasmatic nucleus, PLoS One 6:e15869.

A.J. Davidson, O. Castanon-Cervantes, T. Leise, P. Molyneux, and M. Harrington (2009). Visualizing jet lag in the mouse suprachiasmatic nucleus and peripheral circadian timing system, European Journal of Neuroscience 29(1):171-180.

Eric Bittman and T. Leise (2008). Multi-oscillatory circadian systems. In: Binder, M.D., Hirokawa, N., Windhorst, U. (editors), Encyclopedia of Neuroscience. Springer, Berlin.

T. Leise and Emily Moin (2007). A mathematical model of the Drosophila circadian clock with emphasis on post-translational mechanisms, Journal of Theoretical Biology 28, 48-63.

T. Leise and Hava Siegelmann (2006). Dynamics of a multistage circadian system, Journal of Biological Rhythms 21:4, 314-323.

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